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Oxycodone Mechanism of Action
Oxycodone binds to opioid receptors in the central nervous system (CNS) and produces its pharmacological actions primarily via activation of mu-opioid receptors. Opioids produce their effects by binding to specific receptor sites in the brain and spinal cord. When opioids bind to these receptors, they activate certain nerve cells in the brain and spinal column, causing them to release chemicals called neurotransmitters. These neurotransmitters then affect how the body organs function.
Oxycodone may be prescribed for the relief of moderate to severe pain. It is commonly used to treat moderate to moderately severe pain after surgery, dental procedures, injuries, and burns. It is also used to relieve pain associated with cancer and AIDS.
Oxycodone Side Effect
The most common side effect of oxycodone is constipation. Other possible side effects include nausea, vomiting, dizziness, dry mouth, headache, sweating, confusion, hallucinations, anxiety, difficulty sleeping, and changes in mood.
Oxycodone comes in both immediate-release and extended-release forms. Immediate-release tablets should not be crushed or chewed. Extended-release tablets should be swallowed whole. The usual starting dose of oxycodone is 5 mg taken once daily at bedtime. An increase in dosage may be necessary if initial doses do not provide adequate pain relief. A maximum recommended dose of oxycodone for adults is 40 mg per day.
Overdosing on oxycodone can lead to respiratory depression, coma, and death. If you suspect someone has overdosed on oxycodone, call 911 immediately. Do not give anything by injection. Get medical help right away.
Addiction to oxycodone is rare. However, if you have a history of addiction to any type of narcotic medication, including heroin, morphine, methadone, or prescription medications containing opiates, you should consult your doctor before taking oxycodone.