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Hydrocodone/Acetaminophen for Treating Pain

Hydrocodone/acetaminophen (generic for Vicodin, Lortab, Norco) is a narcotic analgesic used to treat pain. The drug received renewed attention after Darvon and Darvocet were removed from the market on November 19, 2010. As pain medications are removed from the market, fewer options remain for the treatment of chronic pain.

Vicodin was a popular alternative for some Darvocet-users. Vicodin, which was available in tablet form, to be taken orally (by mouth) contained 5 mg hydrocodone bitartrate and 500 mg acetaminophen. There was also Vicodin-ES (7.5 mg hydrocodone bitartrate/750 mg acetaminophen) and Vicodin-HP (10 mg hydrocodone bitartrate/660 mg acetaminophen).

Effective in 2014, the U.S. FDA has applied restrictions to hydrocodone-containing products. The reason: to take action against the abuse of prescription pain medications and make the medications safer. The FDA has limited the amount of acetaminophen to 325 mg. per tablet in hydrocodone-containing products and other prescription combination drugs containing acetaminophen. The FDA has also changed hydrocodone-containing products from schedule III to II which affects how the drugs can be prescribed and obtained.

  • FDA Announces 325 mg. Limit on Acetaminophen in Prescription Combination Drugs in 2011
  • List of Affected Drugs to Be Discontinued or Reformulated by January 14, 2014

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Hydrocodone/acetaminophen is prescribed to relieve moderate to moderately severe pain. Researchers believe that the ingredient hydrocodone relieves pain by changing how the brain and nervous system respond to painful stimuli.Buy Hydrocodone/Acetaminophen online USA,Hydrocodone/Acetaminophen for sale UK,Hydrocodone/Acetaminophen sale online,Hydrocodone/Acetaminophen for sale online,Painkiller for sale online


The dosage of hydrocodone/acetaminophen should be adjusted according to your pain level, without exceeding the total allowable daily dosage. With continued use, a tolerance to hydrocodone can develop, and with increased dosage, there may be increased side effects.

Who Should Not Take It

People who previously exhibited hypersensitivity to hydrocodone or acetaminophen should not take medications with these active ingredients.

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Common Side Effects

Some of the common side effects that may be associated with hydrocodone/acetaminophen include:

  • Lightheadedness
  • Dizziness
  • Sedation
  • Nausea
  • Vomiting

There are also adverse events related to the central nervous system, gastrointestinal system, genitourinary system, respiratory system, the senses, and dermatology:

  • Central nervous system: drowsiness, lethargy, cloudy thinking, impairment of mental and physical performance, anxiety, fear, dysphoria, mood changes, and psychic dependence
  • Gastrointestinal: constipation with prolonged use
  • Genitourinary: ureteral spasm, bladder sphincter spasm, urinary retention
  • Respiratory: respiratory depression that is dose-related
  • Special senses: hearing impairment or hearing loss related to chronic overdose
  • Dermatology: skin rash, pruritis

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Warnings and Precautions

Hydrocodone/acetaminophen should be used with caution in the elderly population and with debilitated patients, patients with severe liver or kidney impairment, hypothyroidism, Addison’s disease, prostatic hypertrophy, or urethral stricture. It should always be remembered that there is the potential for respiratory depression and that the drug suppresses the cough mechanism.Buy Hydrocodone/Acetaminophen online USA,Hydrocodone/Acetaminophen for sale UK,Hydrocodone/Acetaminophen sale online,Hydrocodone/Acetaminophen for sale online,Painkiller for sale online

Patients should use caution when driving and operating machinery while taking hydrocodone/acetaminophen. The drug can be habit-forming, so being aware of your dose will serve you well. If you require more and more to achieve the same therapeutic benefit, talk to your doctor.

Special Instructions for Pregnant Women

Hydrocodone/acetaminophen should be used with caution by pregnant women. Its use during pregnancy may lead to physical dependence or breathing problems in the newborn. Mothers who are breastfeeding should not use hydrocodone/acetaminophen since it is excreted in breast milk.

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Drug Interactions

There may be drug interactions with narcotic analgesics and antihistamines, antipsychotics, anti-anxiety medications, or other central nervous system depressants, including alcohol and sedatives. Your doctor may need to adjust your dose of hydrocodone/acetaminophen if you take any of these drugs.

Signs of Overdose

Signs and symptoms of overdose include respiratory depression, extreme sleepiness that progresses to coma, skeletal muscle flaccidity (limpness), cold or clammy skin, bradycardia (slow heartbeat), and hypotension (low blood pressure). With very severe overdose, there can be apnea, circulatory collapse, cardiac arrest, and death. The acetaminophen portion can result in fatal hepatic necrosis, renal tubular necrosis, hypoglycemic coma, and thrombocytopenia (low platelets).

Article Sources 

  • Vicodin. Abbott. Accessed 3/30/11.
  • Hydrocodone. MedlinePlus. 09/01/2010.